Weight-loss surgery may counter genetic risk for developing breast cancer

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FLORIDA
Women with a genetic predisposition for breast cancer were 2.5 times more likely to develop a malignancy than women with the same genetic risk who underwent bariatric or weight-loss surgery, according to a new study presented today by Cleveland Clinic Florida researchers at the 36th American Society for Metabolic and Bariatric Surgery Annual Meeting at Obesity Week 2019.Breast cancer incidence in women with severe obesity or a body mass index of 35 or higher was found to be 18 percent while incidence for closely matched patients who had weight-loss surgery was 7.4 percent. The study also found that weight-loss surgery cut the overall risk of developing cancers linked to obesity by 20 percent.
For the study, researchers reviewed the data of 1,670,035 patients with a body mass index of 35 or greater collected between 2010 and 2014 in the National Inpatient Sample, the largest all-payer inpatient healthcare database. The incidence of cancer was compared between more than 1.4 million patients who did not undergo bariatric surgery (control group) and nearly 250,000 patients who did.
“Our findings suggest bariatric surgery could significantly prevent the development of cancer in patients with a higher risk than the average population, even in those genetically predisposed,” said study co-author Emanuele Lo Menzo, MD, PhD, FASMBS, Associate Program Director, General Surgery Residency Program, Cleveland Clinic Florida in Weston. “The effect we saw on patients genetically predisposed to developing breast cancer was remarkable and we believe this is the first time a study has shown such an impact. Further studies are needed to determine the factors, including weight loss that may have led to such risk reduction.”
According to the American Cancer Society, having more fat tissue can increase the chances of getting breast cancer by raising estrogen levels. Overweight and obesity are associated with an increased risk of 13 types of cancer, which accounted for about 40 percent of all cancers diagnosed in the United States in 2014, according to the U.S. Centers for Disease Control and Prevention. The American Society of Clinical Oncology calls obesity a major unrecognized risk factor for cancer that has also been associated with an increased risk of recurrence and mortality in patients with cancer.

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